Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
نویسندگان
چکیده
منابع مشابه
Effect of 3-substituted 1,4-benzodiazepin-2-ones on bradykinin-induced smooth muscle contraction.
Biochemical properties of 3-substituted 1,4-benzodiazepine determined by the characteristics of their chemical structure. Influence of 3-substituted 1,4-benzodiazepin-2-ones on maximal normalized rate and amplitudes of isometric smooth muscle contraction in rats was investigated. Compounds MX-1775 and MX-1828 demonstrated the similar inhibition effect on bradykinin-induced contraction of smooth...
متن کاملSynthesis of 3- Benzylidene, 5-Substituted 3-Benzylidene, 3- Hetarylmethylene and 5-Substituted Hetarylmethylene Derivatives of In- dolin-2-ones
A wide variety of titled compounds, several of which have neuro-protecting properties has been prepared in yields ranging between 70 to 90%. The compounds were identified by 1 HNMR, 13 C NMR, 1D and 2D NOE analysis, and HRMS. An investigation of the effect of certain 5-substitutuents on the E to Z ratios in DMSO-d6 was carried out. The 5nitro and 5-acetyl substituents were not isomerized, where...
متن کاملSynthesis and biological evaluation of diversely substituted indolin-2-ones.
The synthesis of indolin-2-one derivatives substituted in the 3-position by an aminomethylene group bearing either an ornithine or a lysine residue is described. The inhibitory activities of these compounds toward a panel of eight kinases were examined. Furthermore, the antibacterial activities of the prepared compounds were tested against two Gram-positive bacteria Bacillus cereus and Streptom...
متن کاملSyntheses of 11-substituted 3-methyl-3,4,10,11-tetrahydro-1H,5H-pyrano[4, 3-b][1,5]benzodiazepin-1-ones.
In the course of our synthetic studies on biologically active compounds using dimedone, tetronic acids, and tetramic acids,1) we reported that some 10-substituted 3,3-dimethyl3, 4, 9, 10tetrahydro1Hfuroand -pyrrolo [4, 3-b] [1, 5] benzodiazepin1-ones (1 and 2) showed analgesic activity as strong as that of aminopyrine in the phenylquinone writhing test in mice.2) Namely, the extents of inhibiti...
متن کاملSynthesis, antiviral and cytotoxic investigation of 2-phenyl-3-substituted quinazolin-4(3H)-ones.
OBJECTIVES A series of 3(benzylideneamino)-2-phenyl quinazoline-4(3H)-ones was synthesized by reaction of 3-amino-2-phenyl-3H-quinazoline-4-one with various carbonyl compounds. MATERIALS AND METHODS Chemical structures of the synthesized compounds were confirmed by IR, 1H-NMR and mass spectral analysis. Title compounds were investigated for cytotoxicity and antiviral activity against herpes s...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 1998
ISSN: 0103-5053
DOI: 10.1590/s0103-50531998000400010